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  • Co-solvents are based on the principles of cohesive energy density. Where a drug shows poor solubility in water, its solubility can often be increased by the addition of a water-miscible solvent in which the drug has good solubility.
  • Complexation uses agents such as cyclodextrins  and their derivatives to form intermolecular complexes. These increase the water solubility, dissolution rate and bioavailability of lipophilic drugs for oral or parenteral delivery.
  • Micellar solubilisation uses solubilising agents capable of forming micellar structures. When the concentration of surfactants exceeds the Critical Micelle Concentration (CMC), the micelles that are then formed trap the drug within their structures in a process known as micellisation.
  • The addition of an electrolyte that does not possess the same ions can raise the solubility of an electrolyte that has limited solubility.


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