OUR CONTRACT PHARMACEUTICAL SERVICES

Company Overview

LIPOPHILIC DRUG FORMULATION TECHNOLOGIES

Identifying the most suitable lipid excipients for the challenges of dispersion, dissolution or digestion.

Read More

Lipophilic systems have proven effectiveness in improving bioavailability by helping drugs to overcome problems like poor gastric solubilisation, degradation and elimination due to first-pass metabolism in the liver, other types of pre-systemic metabolism, and drug transport and efflux effects.

At Quay Pharma, we are highly experienced in identifying the most suitable lipid excipients for the challenges of dispersion, dissolution or digestion that your drug may be encountering, and then developing suitable formulations using oils or surfactant-based systems. We take prototype formulations through comprehensive in vitro testing and characterisation, enabling us to manufacture an optimised product for clinical studies that will give your drug product the best chance of success. We have a wide choice of proven technologies available.

To enhance drug solubility:

  • The surfactant properties of self emulsifying and self micro-emulsifying drug delivery systems (SEDDS and SMEDDS) can be used to improve the dispersion and solubilisation of drugs in the gastrointestinal tract.
  • The digestion of lipid excipients (oils and surfactants) in combination with the drug product can improve solubilisation and absorption in the gastrointestinal tract.

To enhance drug absorption, lipid excipients can be used:

  • To act upon the enterocyte-based transport mechanisms, for example by inhibiting the P-glycoprotein efflux transporter that controls drug uptake and efflux.
  • To facilitate uptake by the lymphatic transport system, thereby eliminating first-pass metabolism in the liver and improving bioavailability.
  • To inhibit pre-systemic enzyme activity, notably from the P450 enzymes, that can increase the cellular concentration of the drug.
Solubility & Bioavailability

pH Control

Adjustment of the pH value for increasing the water solubility of ionisable compounds.

Find Out More

Particle Size Reduction

Where drugs exhibit reduced bioavailability due to poor solubility, the cause is often intrinsically linked with particle size.

Find Out More

Solid Dispersions

Solid dispersions work by dispersing the poorly-soluble drug within a highly soluble solid hydrophilic matrix.

Find Out More

Lipophilic Systems

Highly experienced in identifying the most suitable lipid excipients for the challenges of dispersion, dissolution or digestion

Find Out More

Let's Talk Project Success

Talk directly to the Quay staff - Our dedicated team leaders are ready to listen and help with your project.

Contact Us