Oral liquid dosage forms include solutions, syrups, suspensions, elixirs and concentrates. They offer better patient compliance in people who find swallowing pills or capsules difficult, and more flexible dosage control than a fixed-dose tablet. However, there are particular issues that arise in formulating and developing oral liquid dosages. These include the stability of the drug in solution, the solubility of the drug at the required concentration and the acceptability of the taste.
We have considerable experience of overcoming these challenges through the effective use of excipients to modify the behaviour and properties of the formulation without impeding the efficacy of the API.
Liquid dosage forms are most commonly found in medicines for geriatric and paediatric patients. However, they have certain advantages, including fast efficacy due to the absence of dissolution time and more rapid absorption in the stomach and intestines than tablets. These may be important factors in certain treatments such as pain relief.
Our Oral Liquid Development and Manufacture Includes:
- Paediatric drops
- Flavouring and taste masking
- Sugar-free formulation development